[Lisa_seminaires] [Tea Talk] Anne Churchland (Cold Spring Harbor Laboratory) June 29 2018 10:30 AA3195

Michael Noukhovitch mnoukhov at gmail.com
Mar 26 Juin 14:07:12 EDT 2018


This week we have *Anne Churchland * from * Cold Spring Harbor Laboratory *
giving a talk on *June 29 2018* at *10:30* in room *AA3195*

This talk may be streamed as usual here
<https://mila.bluejeans.com/1365483656/webrtc>
And you can sign up to meet the speaker here
<https://calendar.google.com/calendar/selfsched?sstoken=UVBVTVF0X25Nd09LfGRlZmF1bHR8ZWQ5MmNlYWMxODI4OWVkNmUzNGU3OTE4ZDExMGI0YTk>

Don't even think about it! Decide to come to the tea talk and let your feet
spontaneously guide the way.
Michael

*TITLE* Spontaneous movements dominate cortical activity during
sensory-guided decision making

*KEYWORDS *neuroscience, decision-making, neuro-imaging

*ABSTRACT*
Animals continually produce a wide array of spontaneous and learned
movements and undergo rapid internal state transitions. Most work in
neuroscience ignores this “internal backdrop” and instead focuses on
neural activity aligned to task-imposed variables such as sensory stimuli.
We sought to understand the joint effects of internal backdrop vs.
task-imposed variables. We measured neural activity using calcium imaging
via a widefield macroscope during decision-making. Surprisingly, the impact
of the internal backdrop dwarfed task-imposed sensory and
cognitive signals. This dominance was comparable in novice and expert
decision-makers and was even stronger in single neuron measurements from
frontal cortex. These results highlight spontaneous and learned movements
as the main determinant of large-scale cortical activity. By leveraging a
wide array of animal movements, our model offers a very general method for
separating the impact of internal backdrop from task-imposed
neural activity.

*BIO* Anne K. Churchland received her Ph.D. in neuroscience from the
University of California, San Francisco, advised by Dr. Stephen Lisberger.
She then did a postdoctoral fellowship with Dr. Michael Shadlen at the
University of Washington in the Physiology and Biophysics Department. Her
postdoctoral work focused on mechanisms of decision making in nonhuman
primates and included both experimental and theoretical work. The latter
was funded by a Pathways to Independence (K99) Award from the National Eye
Institute. In 2010, she became an assistant professor at Cold Spring Harbor
Laboratory. In starting her own laboratory, Professor Churchland began
studying decision making using rodent models to take advantage of emerging
tools for circuit dissection which are readily available in rodents. Since
then, her laboratory has been a major player in bringing behavioral
paradigms to rodents that have been successful in elucidating neural
mechanisms in primates. These include perceptual decision making and
multisensory integration. Most recently, she has teamed up with other 20
other researchers to for the International Brain Laboratory, a
collaboration between theorists and experimentalists aiming to understand
the neural computations supporting decision-making. Since joining Cold
Spring Harbor Laboratory, Professor Churchland has been the recipient of
awards from the McKnight Foundation, the Pew Charitable Trusts, the
Klingenstein-Simons Foundation, the Simons Collaboration on the Global
Brain, the John Merck Fund and the Chapman Foundations. In addition to her
scientific work, Professor Churchland runs science outreach activities at
public schools and co-directed the Undergraduate Research Program at Cold
Spring Harbor Laboratory. She also maintains a blog about neuroscience
research that is directed at a mainstream audience; its recent focus is on
reviewing papers on the preprint server. Professor Churchland also funded
anneslist.net, a resource highlighting women in systems and computational
neuroscience. She received the 2017 Louise Hanson Marshall Special
Recognition Award from the Society for Neuroscience for promoting diversity
in the field and the 2012 Janett Rosenberg Trubatch Career Development
Award for creativity in research prior to tenure.
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